The acknowledged affect of these PTMs on ATXN2’s function and SCA2 pathogenesis remains restricted. In other polyQ diseases, multiple studies suggested that proteolytic cleavage of polyQ proteins could Participate in a significant job in pathogenesis [36, 45]. Aligned with this particular idea, the existence of the enriched 42 kDa fragment while https://connerydhqt.blogprodesign.com/50281631/gizzerosine-hcl-no-further-a-mystery