Chemotherapy was potentiated by E7449 and solitary agent had important antitumor exercise in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, most likely via TNKS inhibition. Per this chance, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and appreciably altered expression https://1-methyl-3--4--4--8-oxa-348025.blogripley.com/30252674/the-2-minute-rule-for-apigenin